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This isolated peptide, Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Sve-Val-Glu-Gly-Ser-Cys-Gly-Phe , retains the ability to stimulate beta-oxidation and inhibit lipogenesis but lacks the domain required to bind to the primary HGH receptor responsible for IGF-1 release and insulin antagonism

The molecule was characterized as a competitive inhibitor of the NNMT active site that uses nicotinamide as substrate

Semaglutide works by mimicking GLP-1, a hormone that helps control blood sugar levels by causing the pancreas to release insulin, decreasing the production of glucagon, and slowing down the emptying of the stomach